RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-145a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Immunofluorescence; etc.
Target
Klf4
Pathway
NA
PubMed ID
Title
MiR-145 regulates myofibroblast differentiation and lung fibrosis
Year
2013
Function
"MiR-145 expression is upregulated in TGF-B1-treated lung fibroblasts and in the lungs of patients with idiopathic pulmonary fibrosis as compared to in normal human lungs. Overexpression of miR-145 in lung fibroblasts increased SMA-a expression, enhanced contractility, and promoted formation of focal and fibrillar adhesions by targeting KLF4, a known negative regulator of SMA-a expression."